ea0056gp114 | Diabetes Translational | ECE2018
Florido-Neto Armando
, Agostini Lucas
, Panveloski-Costa Ana Carolina
, Nunes Maria Tereza
Diabetes mellitus (DM) is a disease that results from impairment of insulin synthesis/secretion or signaling. The glycemia of type 1 DM (DM1) patients is controlled by insulin replacement therapy, which chronically results in insulin resistance. We have shown that alloxan-induced diabetic rats present hypothyroidism, and that T3 treatment reduced the inflammatory state and hepatic glucose production and increased insulin sensitivity, improving glycemia control. Considering tha...